Cometh the Hour opens with the reading of a suicide note, which has devastating consequences for Harry and Emma Clifton, Giles Barrington and Lady Virginia.

Giles must decide if he should withdraw from politics and try to rescue Karin, the woman he loves, from behind the Iron Curtain. But is Karin truly in love with him, or is she a spy?

Lady Virginia is facing bankruptcy, and can see no way out of her financial problems until she is introduced to the hapless Cyrus T. Grant III from Baton Rouge, Louisiana.

Sebastian Clifton is now the Chief Executive of Farthings Bank, and a workaholic whose personal life is thrown into disarray when he falls for Priya, a beautiful Indian girl. But her parents have already chosen the man she is going to marry. Meanwhile, Sebastians rivals Sloane and Mellor are still plotting to bring him down, so they can take over Farthings.

Harry Clifton remains determined to get Anatoly Babakov released from a gulag in Siberia, following the international success of his acclaimed book, Uncle Joe. Harrys wife, Emma, convinces her new friend Margaret Thatcher to raise the subject with the Russian President when she visits Moscow. But then something unexpected happens that none of them could have anticipated.