In Taisho-era Japan, Tanjiro Kamado is a kindhearted boy who makes a living selling charcoal. But his peaceful life is shattered when a demon slaughters his entire family. His little sister Nezuko is the only survivor, but she has been transformed into a demon herself! Tanjiro sets out on a dangerous journey to find a way to return his sister to normal and destroy the demon who ruined his life.

After a fierce battle with a demon inside a maddening house of ever-changing rooms, Tanjiro has a chance to find out about the fighter in the boar-head mask. Who is this passionate swordsman and what does he want? Later, a new mission has Tanjiro and his compatriots heading for Mt. Natagumo and a confrontation with a mysterious and horrifying threat...